The effect of laminins on chemoresistance of colorectal cancer cells

Abstract

Earlier, the data on the ability of laminin-332 to protect liver cancer cells from apoptosis caused by doxorubicin, sorafenib, and gefitinib have been obtained. In order to answer the question whether this action of laminins is common for cancer cells of other types, we estimated the effect of several laminin isoforms on the survival of two colorectal cancer cell lines (RKO and SW-480) when treated with chemotherapeutic agents used in the colon cancer therapy (5-fluorouracil, regorafenib, and sorafenib). The data obtained suggest that this action of laminins is not universal and is likely governed by individual features of cancer cells.