2 H -Benzimidazole  N -oxides: synthesis, chemical properties, and biological activity

E. A. Chugunova; V. A. Samsonov; A. S. Gazizov; A. R. Burilov; M. A. Pudovik; O. G. Sinyashin

doi:10.1007/s11172-018-2315-0

2H-Benzimidazole N-oxides: synthesis, chemical properties, and biological activity

Autores: Chugunova E.A.¹, Samsonov V.A.², Gazizov A.S.¹, Burilov A.R.¹, Pudovik M.A.¹, Sinyashin O.G.¹
Afiliações:
1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
2. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Edição: Volume 67, Nº 11 (2018)
Páginas: 1955-1970
Seção: Reviews
URL: https://journals.rcsi.science/1066-5285/article/view/243151
DOI: https://doi.org/10.1007/s11172-018-2315-0
ID: 243151

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The review presents and summarizes comprehensive data starting from 2006 on the synthesis of mono- and di-N-oxides of 2H-benzimidazoles and their chemical properties. Especial attention was paid to the chemical transformations of 2H-benzimidazole 1,3-dioxides upon heating to give 3H-2,1,4-benzoxadiazine 4-oxides and 2H-benzimidazole mono-N-oxides. The biological activity of compounds was covered.