2H-Benzimidazole N-oxides: synthesis, chemical properties, and biological activity
- Authors: Chugunova E.A.1, Samsonov V.A.2, Gazizov A.S.1, Burilov A.R.1, Pudovik M.A.1, Sinyashin O.G.1
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Affiliations:
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 67, No 11 (2018)
- Pages: 1955-1970
- Section: Reviews
- URL: https://journals.rcsi.science/1066-5285/article/view/243151
- DOI: https://doi.org/10.1007/s11172-018-2315-0
- ID: 243151
Cite item
Abstract
The review presents and summarizes comprehensive data starting from 2006 on the synthesis of mono- and di-N-oxides of 2H-benzimidazoles and their chemical properties. Especial attention was paid to the chemical transformations of 2H-benzimidazole 1,3-dioxides upon heating to give 3H-2,1,4-benzoxadiazine 4-oxides and 2H-benzimidazole mono-N-oxides. The biological activity of compounds was covered.
About the authors
E. A. Chugunova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Author for correspondence.
Email: chugunova.e.a@gmail.com
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
V. A. Samsonov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: chugunova.e.a@gmail.com
Russian Federation, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
A. S. Gazizov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: chugunova.e.a@gmail.com
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
A. R. Burilov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: chugunova.e.a@gmail.com
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
M. A. Pudovik
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: chugunova.e.a@gmail.com
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
O. G. Sinyashin
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: chugunova.e.a@gmail.com
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088