The distribution of complexes 69mZnL1Cl2, [69mZn(L2)2]Cl2, and [69mZn(L2)2]Sal2 (L1 is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L2 is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice


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The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide 69mZn in the organs of mice and its rate of excretion were studied. A solution of ZnCl2 was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed.

作者简介

M. Orlova

Department of Chemistry, M. V. Lomonosov Moscow State University; D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology

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Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997

T. Trofimova

Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432

G. Aleshin

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991

S. Belyshev

Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University

Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 19, 1 Leninskie Gory, Moscow, 119991

A. Orlov

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991

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