The distribution of complexes 69mZnL1Cl2, [69mZn(L2)2]Cl2, and [69mZn(L2)2]Sal2 (L1 is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L2 is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice
- 作者: Orlova M.A.1,2, Trofimova T.P.1,3, Aleshin G.Y.1, Belyshev S.S.4, Orlov A.P.1
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隶属关系:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
- 期: 卷 67, 编号 8 (2018)
- 页面: 1542-1543
- 栏目: Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242920
- DOI: https://doi.org/10.1007/s11172-018-2254-9
- ID: 242920
如何引用文章
详细
The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide 69mZn in the organs of mice and its rate of excretion were studied. A solution of ZnCl2 was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed.
作者简介
M. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
编辑信件的主要联系方式.
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997
T. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
G. Aleshin
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991
S. Belyshev
Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 19, 1 Leninskie Gory, Moscow, 119991
A. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991
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