Conversion of carbonyl steroid derivatives to 1,1-dibromoalkenes by the catalytic olefination reaction and synthesis of functionally substituted steroids on their basis
- Авторы: Kazantsev A.V.1, Lukashev N.V.1, Nenajdenko V.G.1
- 
							Учреждения: 
							- M. V. Lomonosov Moscow State University, Department of Chemistry
 
- Выпуск: Том 67, № 3 (2018)
- Страницы: 530-534
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242360
- DOI: https://doi.org/10.1007/s11172-018-2106-7
- ID: 242360
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Аннотация
Catalytic olefination of carbonyl steroid derivatives were used to obtain the corresponding 1,1-dibromoalkenes. For this, N-unsubstituted steroid hydrazones were involved into the reaction with tetrabromomethane in the presence of copper(i) chloride. The dibromides can be used for the synthesis of various functionalized steroids by conversion of a dibromomethylidene fragment to the carboxy, amide, and phosphonate groups.
Об авторах
A. Kazantsev
M. V. Lomonosov Moscow State University, Department of Chemistry
														Email: nenajdenko@gmail.com
				                					                																			                												                	Россия, 							Build. 3, 1 Leninskie Gory, Moscow, 119991						
N. Lukashev
M. V. Lomonosov Moscow State University, Department of Chemistry
														Email: nenajdenko@gmail.com
				                					                																			                												                	Россия, 							Build. 3, 1 Leninskie Gory, Moscow, 119991						
V. Nenajdenko
M. V. Lomonosov Moscow State University, Department of Chemistry
							Автор, ответственный за переписку.
							Email: nenajdenko@gmail.com
				                					                																			                												                	Россия, 							Build. 3, 1 Leninskie Gory, Moscow, 119991						
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