Nitrosylsulfuric acid as an oxidant in the synthesis of 3,5-diarylisoxazoles
- Authors: Bondarenko O.B.1, Komarov A.I.1, Kuznetsova L.I.1, Nikolaeva S.N.1, Gavrilova A.Y.1, Zyk N.V.1,2
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Affiliations:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Issue: Vol 67, No 3 (2018)
- Pages: 517-520
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/242344
- DOI: https://doi.org/10.1007/s11172-018-2103-x
- ID: 242344
Cite item
Abstract
By six examples, it was demonstrated that nitrosylsulfuric acid can be successfully used for oxidation of 3,5-diaryl-4,5-dihydroisoxazoles to the corresponding 3,5-diarylisoxazoles. If the starting isoxazolines contain the aromatic substituents activated towards electrophilic substitution, nitration of both newly formed isoxazole and substituted benzene rings occurred.
About the authors
O. B. Bondarenko
Department of Chemistry, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: k527.5msu@gmail.com
Russian Federation, 1 Leninskie Gory, Moscow, 119992
A. I. Komarov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: k527.5msu@gmail.com
Russian Federation, 1 Leninskie Gory, Moscow, 119992
L. I. Kuznetsova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: k527.5msu@gmail.com
Russian Federation, 1 Leninskie Gory, Moscow, 119992
S. N. Nikolaeva
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: k527.5msu@gmail.com
Russian Federation, 1 Leninskie Gory, Moscow, 119992
A. Yu. Gavrilova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: k527.5msu@gmail.com
Russian Federation, 1 Leninskie Gory, Moscow, 119992
N. V. Zyk
Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: k527.5msu@gmail.com
Russian Federation, 1 Leninskie Gory, Moscow, 119992; 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432