Experimental study of the antitumor effect of aurumacryl
- Authors: Ostrovskaya L.A.1, Korman D.B.1, Grehova A.K.1, Osipov A.N.2, Bluhterova N.V.1, Fomina M.M.1, Rikova V.A.1, Abzaeva K.A.3
- 
							Affiliations: 
							- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
- A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
 
- Issue: Vol 66, No 12 (2017)
- Pages: 2333-2338
- Section: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/241870
- DOI: https://doi.org/10.1007/s11172-017-2025-z
- ID: 241870
Cite item
Abstract
Gold polyacrylate (aurumacryl) belonging to a new class of compounds for oncology — metal polyacrylates — was shown to exhibit strong antitumor activity. Aurumacryl causes 80—90% growth inhibition in vivo of murine solid tumors (Lewis lung carcinoma, Ca-755 adenocarcinoma, and Acatol adenocarcinoma) compared to the control and induces cell death in vitro in 60% of MCF-7 human breast carcinoma cells. Substantial changes in proliferation kinetics of the surviving fraction of tumor cells following treatment with aurumacryl were observed, which are related to the predominant accumulation (93%) of cells in the proliferative resting phase G0 and a substantial decrease in the percentage of proliferating cells (7%). These data provide evidence that the cells that survive lose reproductive ability under treatment with aurumacryl.
About the authors
L. A. Ostrovskaya
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
							Author for correspondence.
							Email: larros@list.ru
				                					                																			                												                	Russian Federation, 							4 ul. Kosygina, Moscow, 119334						
D. B. Korman
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Russian Federation, 							4 ul. Kosygina, Moscow, 119334						
A. K. Grehova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Russian Federation, 							4 ul. Kosygina, Moscow, 119334						
A. N. Osipov
A. I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency
														Email: larros@list.ru
				                					                																			                												                	Russian Federation, 							46 ul. Zhivopisnaya, Moscow, 123098						
N. V. Bluhterova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Russian Federation, 							4 ul. Kosygina, Moscow, 119334						
M. M. Fomina
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Russian Federation, 							4 ul. Kosygina, Moscow, 119334						
V. A. Rikova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Russian Federation, 							4 ul. Kosygina, Moscow, 119334						
K. A. Abzaeva
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
														Email: larros@list.ru
				                					                																			                												                	Russian Federation, 							1 ul. Favorskogo, Irkutsk, 664033						
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