Email this article A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid chromatography
- Authors: Pokrovskiy O.I.1, Kostenko M.O.2, Lunin V.V.1,2
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Affiliations:
- N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Issue: Vol 66, No 11 (2017)
- Pages: 2190-2193
- Section: Brief Communication
- URL: https://journals.rcsi.science/1066-5285/article/view/241725
- DOI: https://doi.org/10.1007/s11172-017-2001-7
- ID: 241725
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Abstract
non-monotonous dependence of selectivity coefficient on pressure in the enantioseparation of salbutamol sulfate by supercritical fluid chromatography was discovered. When increasing the isothermal pressure of the mobile phase in the interval 100—200 bar at a temperature of 20 °С, the selectivity coefficient of separation of salbutamol enantiomers first increased, then decreased, followed by another increase. Such a behavior is atypical and determines the expediency of using pressure to control selectivity in this kind of chromatography.
About the authors
O. I. Pokrovskiy
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: oleg.pokrovskiy@supercritical.ru
Russian Federation, 31 Leninsky prosp., Moscow, 119991
M. O. Kostenko
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: oleg.pokrovskiy@supercritical.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
V. V. Lunin
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Department of Chemistry, M. V. Lomonosov Moscow State University
Email: oleg.pokrovskiy@supercritical.ru
Russian Federation, 31 Leninsky prosp., Moscow, 119991; Build. 3, 1 Leninskie Gory, Moscow, 119991
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