Email this article Kinetic characteristics of the reaction of resveratrol with peroxyl radicals and natural thiols in aqueous medium
- Authors: Zinatullina K.M.1,2,3, Khrameeva N.P.2, Kasaikina O.T.1,3,4, Shapiro B.I.2, Kuzmin V.A.2,4
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Affiliations:
- N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- P. G. Demidov Yaroslavl State University
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Issue: Vol 66, No 11 (2017)
- Pages: 2145-2151
- Section: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/241654
- DOI: https://doi.org/10.1007/s11172-017-1995-1
- ID: 241654
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Abstract
The method of competing reactions was used to determine the rate constants of the reaction of resveratrol (RVT) with peroxyl radicals formed on decomposition of the azoinitiator ААРН in aqueous solutions at 37 °С. The polymethine dye A (3,3′-di-γ-sulfopropyl-9-metylthiacarbocyanine-betaine pyridinium salt) was used as a competing acceptor of radicals. It was found that resveratrol can be involved in the reaction with natural thiols, glutathione (GSH) and cysteine (CSH), in aqueous solutions at 37 °С. The reaction of RVT with thiols (thiol—еne reaction) follows a chain mechanism and accelerates in the presence of Н2О2. The results obtained can be useful for understanding the physiological role of thiols in oxidation processes.
About the authors
K. M. Zinatullina
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; P. G. Demidov Yaroslavl State University
Author for correspondence.
Email: karinazinat11@gmail.com
Russian Federation, 4 ul. Kosygina, Moscow, 119991; 4 ul. Kosygina, Moscow, 119991; 14 ul. Sovetskaya, Yaroslavl, 150000
N. P. Khrameeva
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: karinazinat11@gmail.com
Russian Federation, 4 ul. Kosygina, Moscow, 119991
O. T. Kasaikina
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences; P. G. Demidov Yaroslavl State University; Department of Chemistry, M. V. Lomonosov Moscow State University
Email: karinazinat11@gmail.com
Russian Federation, 4 ul. Kosygina, Moscow, 119991; 14 ul. Sovetskaya, Yaroslavl, 150000; Build. 3, 1 Leninskie Gory, Moscow, 119991
B. I. Shapiro
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: karinazinat11@gmail.com
Russian Federation, 4 ul. Kosygina, Moscow, 119991
V. A. Kuzmin
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Department of Chemistry, M. V. Lomonosov Moscow State University
Email: karinazinat11@gmail.com
Russian Federation, 4 ul. Kosygina, Moscow, 119991; Build. 3, 1 Leninskie Gory, Moscow, 119991
