Email this article Biological activity of some sulfur- and selenium-containing spiro compounds
- Authors: Proshin A.N.1, Orlova M.A.2,3, Trofimova T.P.2,3
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Affiliations:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
- Issue: Vol 66, No 10 (2017)
- Pages: 1931-1933
- Section: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/241483
- DOI: https://doi.org/10.1007/s11172-017-1968-4
- ID: 241483
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Abstract
Cytotoxicity to K-562 leukemia cell line of two spiro compounds containing selenium or sulfur atom in their structure were compared. 4-Fluorophenyl-(1-thia-3-azaspiro[5.5]undec-2-en-2-yl]amine hydrobromide was synthesized and characterized for the first time. It was found that the introduction of a sulfur atom is more promising for this biological model, since it leads to a 3-fold increase in the therapeutic index in the case of the sulfur-containing compound.
About the authors
A. N. Proshin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Russian Federation, 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
M. A. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Author for correspondence.
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; I ul. Samory Mashela, Moscow, 117997
T. P. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; I ul. Samory Mashela, Moscow, 117997
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