Structure—hemolytic activity relationship in isobornylphenol derivatives

O. G. Shevchenko; S. N. Plyusnina; E. V. Buravlev; I. Yu. Chukicheva; I. V. Fedorova; O. V. Shchukina; A. V. Kutchin

doi:10.1007/s11172-017-1962-x

Structure—hemolytic activity relationship in isobornylphenol derivatives

Authors: Shevchenko O.G.¹, Plyusnina S.N.¹, Buravlev E.V.², Chukicheva I.Y.², Fedorova I.V.², Shchukina O.V.², Kutchin A.V.²
Affiliations:
1. Institute of Biology, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences
2. Institute of Chemistry, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences
Issue: Vol 66, No 10 (2017)
Pages: 1881-1890
Section: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/241451
DOI: https://doi.org/10.1007/s11172-017-1962-x
ID: 241451

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Abstract

A structure — hemolytic activity relationship in isobornylphenol derivatives was analysed. The morphological transformation of erythrocytes under the influence of some representatives of this class of compounds was demonstrated by scanning electron microscopy. The hemolytic activity of the test compounds can vary within wide limits, depending on the structure and position of substituents determining the nature of the interaction of the compound with the cell membrane.

Keywords

terpenylphenols, isobornylphenols, aminomethylphenols, alkoxymethylphenols, antioxidants, erythrocyte, biomembrane, hemolysis, morphological transformation of erythrocytes, scanning electron microscopy

About the authors

O. G. Shevchenko

Institute of Biology, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences

Email: chukichevaiy@mail.ru
Russian Federation, 28 ul. Kommunisticheskaya, Syktyvkar, 167982