电邮这篇文章 Zinc-containing derivatives of 2-aminopyrimidine
- 作者: Orlov A.P.1, Trofimova T.P.1,2, Osipova E.Y.2, Proshin A.N.3, Orlova M.A.1,2
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隶属关系:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
- Institute of Physiological Active Compounds, Russian Academy of Sciences
- 期: 卷 66, 编号 10 (2017)
- 页面: 1860-1866
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/241429
- DOI: https://doi.org/10.1007/s11172-017-1958-6
- ID: 241429
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详细
A platform containing three anticancer components is proposed. The components are a radioactive 69mZn isotope and zinc complexes, where both zinc and ligand exhibit anticancer properties. Two zinc-containing complexes, namely (2-AP)2ZnCl2 and (2-AP)2Zn(Sal)2 (AP is 2-aminopyrimidine, Sal is salicylate) were synthesized and characterized. Their cytotoxicity with respect to some leukemia cell lines is demonstrated. Their stability in physiological solution and percentage of apoptosis (by flow cytometry) are investigated. Stable complexes of compounds with the isotope 69mZn were characterized by TLC and autoradiography.
作者简介
A. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991
T. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997
E. Osipova
Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Email: orlova.radiochem@mail.ru
俄罗斯联邦, 1 ul. Samory Mashela, Moscow, 117997
A. Proshin
Institute of Physiological Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
俄罗斯联邦, 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
M. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
编辑信件的主要联系方式.
Email: orlova.radiochem@mail.ru
俄罗斯联邦, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997
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