Email this article Zinc-containing derivatives of 2-aminopyrimidine
- Authors: Orlov A.P.1, Trofimova T.P.1,2, Osipova E.Y.2, Proshin A.N.3, Orlova M.A.1,2
-
Affiliations:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
- Institute of Physiological Active Compounds, Russian Academy of Sciences
- Issue: Vol 66, No 10 (2017)
- Pages: 1860-1866
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/241429
- DOI: https://doi.org/10.1007/s11172-017-1958-6
- ID: 241429
Cite item
Open Access
Access granted
Subscription Access
Abstract
A platform containing three anticancer components is proposed. The components are a radioactive 69mZn isotope and zinc complexes, where both zinc and ligand exhibit anticancer properties. Two zinc-containing complexes, namely (2-AP)2ZnCl2 and (2-AP)2Zn(Sal)2 (AP is 2-aminopyrimidine, Sal is salicylate) were synthesized and characterized. Their cytotoxicity with respect to some leukemia cell lines is demonstrated. Their stability in physiological solution and percentage of apoptosis (by flow cytometry) are investigated. Stable complexes of compounds with the isotope 69mZn were characterized by TLC and autoradiography.
Keywords
About the authors
A. P. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
T. P. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997
E. Yu. Osipova
Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Email: orlova.radiochem@mail.ru
Russian Federation, 1 ul. Samory Mashela, Moscow, 117997
A. N. Proshin
Institute of Physiological Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Russian Federation, 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
M. A. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology
Author for correspondence.
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997
