Bis(4-nitrobenzenethiolato)tetranitrosyldiiron: synthesis, structure, and pharmacological activity of a new nitric oxide (NO) donor


Дәйексөз келтіру

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

A preparative procedure was developed for the synthesis of new binuclear tetranitrosyl iron complex of the “μ-S” structural type, [Fe2(SC6H4NO2)2(NO)4] (1), comprising the replacement of the thiosulfate ligands in Na2[Fe2(S2O3)2(NO)4]•4H2O by anions of the 4-nitrobenzenethiolate hydrazinium salt. The salt was obtained by the reduction of bis(4-nitrophenyl) disulfide with hydrazine hydrate in ethanol. The physicochemical properties of the complex in the solid state were studied by IR and Mössbauer spectroscopy. According to amperometric measurements in aqueous solutions, the complex generates NO in a protic medium without additional photo, thermal, or redox activation, providing prolonged release of NO, since the para-positioned nitro group in the aromatic ligand functions as an additional NO source. A study of the pharmacological activity by the MTT assay showed that the complex possesses a high cytotoxic activity against the MCF7 human breast cancer cells (IC50 = 47 μmol L–1) and an antibacterial activity against gram-negative (E. coli, BB strain) and gram-positive (M. luteus, 21/26 strain) microorganisms.

Авторлар туралы

N. Sanina

Institute of Problems of Chemical Physics, Russian Academy of Sciences; Faculty of Fundamental Physical and Chemical Engineering, M. V. Lomonosov Moscow State University; Moscow Region State University

Хат алмасуға жауапты Автор.
Email: sanina@icp.ac.ru
Ресей, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432; build. 51, 1 Leninskie gory, Moscow, 119991; 10a ul. Radio, Moscow, 105005

G. Kozub

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Ресей, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

T. Kondrat´eva

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Ресей, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

A. Terent´ev

Institute of Problems of Chemical Physics, Russian Academy of Sciences; Faculty of Fundamental Physical and Chemical Engineering, M. V. Lomonosov Moscow State University; Moscow Region State University

Email: sanina@icp.ac.ru
Ресей, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432; build. 51, 1 Leninskie gory, Moscow, 119991; 10a ul. Radio, Moscow, 105005

V. Mumyatova

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Ресей, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

P. Barzilovich

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Ресей, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

N. Ovanesyan

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Ресей, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

S. Aldoshin

Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow Region State University

Email: sanina@icp.ac.ru
Ресей, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432; 10a ul. Radio, Moscow, 105005

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