Synthesis of 1,1´-[methylenebis(oxy)]bis[3-alkyl-3-(2-haloethyl)triaz-1-ene 2-oxides]

G. V. Pokhvisneva; T. V. Ternikova; G. A. Smirnov; P. B. Gordeev; S. V. Nikitin; O. A. Luk´yanov

doi:10.1007/s11172-017-1878-5

Synthesis of 1,1´-[methylenebis(oxy)]bis[3-alkyl-3-(2-haloethyl)triaz-1-ene 2-oxides]

Authors: Pokhvisneva G.V.¹, Ternikova T.V.¹, Smirnov G.A.¹, Gordeev P.B.¹, Nikitin S.V.¹, Luk´yanov O.A.¹
Affiliations:
1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Issue: Vol 66, No 7 (2017)
Pages: 1234-1239
Section: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/240940
DOI: https://doi.org/10.1007/s11172-017-1878-5
ID: 240940

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Abstract

A method for the synthesis of promising nitric oxide donors in living organisms, 1,1´-[methylenebis(oxy)]bis[3-alkyl-3-(2-haloethyl)triaz-1-ene 2-oxides] was elaborated. The method involved replacement of hydroxy groups of the corresponding 1,1´-[methylenebis(oxy)]bis[3-alkyl-3-(2-hydroxyethyl)triaz-1-ene 2-oxides] by halogen atoms and, in some cases, the exchange of one halogen atom for another.