Enviar artigo por via de e-mail Effects of some 5-anilino-1,2,4-thiadiazole derivatives onto leukemic cells
- Autores: Orlova M.A.1,2, Trofimova T.P.1,2, Proshin A.N.3, Orlov A.P.1
-
Afiliações:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
- Department of Organic Synthesis, Institute of Physiological Active Compounds of Russian Academy of Sciences
- Edição: Volume 66, Nº 5 (2017)
- Páginas: 932-934
- Seção: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/240654
- DOI: https://doi.org/10.1007/s11172-017-1833-5
- ID: 240654
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
The antileukemic activities of some thiadiazole derivatives in the forms of hydrochlorides and salicylates have been determined. The insertion of salicylate ion in the compound increases the therapeutic index, mainly due to the reduction of cytotoxicity against healthy cells.
Palavras-chave
Sobre autores
M. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
Autor responsável pela correspondência
Email: Orlova.radiochim@mail.ru
Rússia, Bld. 3, 1 Leninskie Gory, Moscow, 119992; 1 ul. Samora Mashel, Moscow, 117997
T. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
Email: Orlova.radiochim@mail.ru
Rússia, Bld. 3, 1 Leninskie Gory, Moscow, 119992; 1 ul. Samora Mashel, Moscow, 117997
A. Proshin
Department of Organic Synthesis, Institute of Physiological Active Compounds of Russian Academy of Sciences
Email: Orlova.radiochim@mail.ru
Rússia, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: Orlova.radiochim@mail.ru
Rússia, Bld. 3, 1 Leninskie Gory, Moscow, 119992
Arquivos suplementares
