Email this article Effects of some 5-anilino-1,2,4-thiadiazole derivatives onto leukemic cells
- Authors: Orlova M.A.1,2, Trofimova T.P.1,2, Proshin A.N.3, Orlov A.P.1
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Affiliations:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
- Department of Organic Synthesis, Institute of Physiological Active Compounds of Russian Academy of Sciences
- Issue: Vol 66, No 5 (2017)
- Pages: 932-934
- Section: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/240654
- DOI: https://doi.org/10.1007/s11172-017-1833-5
- ID: 240654
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Abstract
The antileukemic activities of some thiadiazole derivatives in the forms of hydrochlorides and salicylates have been determined. The insertion of salicylate ion in the compound increases the therapeutic index, mainly due to the reduction of cytotoxicity against healthy cells.
About the authors
M. A. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
Author for correspondence.
Email: Orlova.radiochim@mail.ru
Russian Federation, Bld. 3, 1 Leninskie Gory, Moscow, 119992; 1 ul. Samora Mashel, Moscow, 117997
T. P. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, D. Rogachev Federal Clinical Center of Pediatric Hematology, Oncology and Immunology
Email: Orlova.radiochim@mail.ru
Russian Federation, Bld. 3, 1 Leninskie Gory, Moscow, 119992; 1 ul. Samora Mashel, Moscow, 117997
A. N. Proshin
Department of Organic Synthesis, Institute of Physiological Active Compounds of Russian Academy of Sciences
Email: Orlova.radiochim@mail.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. P. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: Orlova.radiochim@mail.ru
Russian Federation, Bld. 3, 1 Leninskie Gory, Moscow, 119992
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