Nitrobenzoxadiazole derivatives as nitric oxide donors: ESR study using spin trapping
- Authors: Serezhenkov V.A.1, Tkachev N.A.1, Semenyuk Y.P.2, Kurbatov S.V.2, Kharchenko E.Y.2, Chistyakov V.A.2
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Affiliations:
- N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
- Southern Federal University
- Issue: Vol 66, No 1 (2017)
- Pages: 76-82
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239809
- DOI: https://doi.org/10.1007/s11172-017-1702-2
- ID: 239809
Cite item
Abstract
The ability of nitrobenzoxadiazoles to induce the SOX-operon from a genetically engineered biosensor based on E. coli MG 1655 (pSoxS-lux) was confirmed by the fact of producing nitric oxide. The NO-donating properties of three nitrobenzoxadiazole derivatives bearing π-excessive carbo- and heterocycles were found by the ESR method using spin trapping. The yield of nitrogen(II) oxide was 17, 0.3, and 1.6%. Sodium sulfide accelerates the thiol-dependent transformation and increases the yield of nitric oxide to 27, 16, and 12%, respectively.
About the authors
V. A. Serezhenkov
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: serezhenkov@polymer.chph.ras.ru
Russian Federation, 4 ul. Kosygina, Moscow, 109991
N. A. Tkachev
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
Email: serezhenkov@polymer.chph.ras.ru
Russian Federation, 4 ul. Kosygina, Moscow, 109991
Yu. P. Semenyuk
Southern Federal University
Email: serezhenkov@polymer.chph.ras.ru
Russian Federation, 194/1 prosp. Stachki, Rostov-on-Don, 344090
S. V. Kurbatov
Southern Federal University
Email: serezhenkov@polymer.chph.ras.ru
Russian Federation, 194/1 prosp. Stachki, Rostov-on-Don, 344090
E. Yu. Kharchenko
Southern Federal University
Email: serezhenkov@polymer.chph.ras.ru
Russian Federation, 194/1 prosp. Stachki, Rostov-on-Don, 344090
V. A. Chistyakov
Southern Federal University
Email: serezhenkov@polymer.chph.ras.ru
Russian Federation, 194/1 prosp. Stachki, Rostov-on-Don, 344090