Email this article Synthesis and cytotoxic activity of Boc-protected pentapeptide amide analogs of somatostatin
- Authors: Balaev A.N.1, Osipov V.N.1,2, Okhmanovich K.A.1, Ruchko E.A.1, Kolotaev A.V.2, Khachatryan D.S.2
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Affiliations:
- Pharm-Sintez
- State Scientific-Research Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
- Issue: Vol 65, No 11 (2016)
- Pages: 2766-2769
- Section: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/239481
- DOI: https://doi.org/10.1007/s11172-016-1651-1
- ID: 239481
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Abstract
New Boc-protected pentapeptide amides of the general formula Boc—Cys(Boc)—Phe—d-Trp—Lys(Boc)—Thr—NHR, which are analogs of the natural hormone somatostatin, were synthesized. The cytotoxic activity of the new compounds was evaluated against the cancer cell lines MCF-7, PC 3, and HCT-116 by the MTT test, and some of these compounds were found to exhibit activity at micromolar concentrations.
About the authors
A. N. Balaev
Pharm-Sintez
Email: ovn65@yandex.ru
Russian Federation, 29, Build. 134, ul. Vereiskaya, Moscow, 121357
V. N. Osipov
Pharm-Sintez; State Scientific-Research Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Author for correspondence.
Email: ovn65@yandex.ru
Russian Federation, 29, Build. 134, ul. Vereiskaya, Moscow, 121357; 3 Bogorodskiy val, Moscow, 107076
K. A. Okhmanovich
Pharm-Sintez
Email: ovn65@yandex.ru
Russian Federation, 29, Build. 134, ul. Vereiskaya, Moscow, 121357
E. A. Ruchko
Pharm-Sintez
Email: ovn65@yandex.ru
Russian Federation, 29, Build. 134, ul. Vereiskaya, Moscow, 121357
A. V. Kolotaev
State Scientific-Research Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: ovn65@yandex.ru
Russian Federation, 3 Bogorodskiy val, Moscow, 107076
D. S. Khachatryan
State Scientific-Research Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: ovn65@yandex.ru
Russian Federation, 3 Bogorodskiy val, Moscow, 107076
