Synthesis of γ-carbolines containing NO-donor fragment and assessment of their anticholinesterase activity
- 作者: Bachurin S.O.1, Ustinov A.K.1, Serkov I.V.1, Proshin A.N.1, Kovaleva N.V.1, Boltneva N.P.1, Makhaeva G.F.1
- 
							隶属关系: 
							- Institute of Physiologically Active Compounds, Russian Academy of Sciences
 
- 期: 卷 65, 编号 11 (2016)
- 页面: 2718-2721
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/239401
- DOI: https://doi.org/10.1007/s11172-016-1641-3
- ID: 239401
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详细
Hybrid γ-carboline-based compounds containing a nitrooxy group as an NO-donor were prepared. It was shown that the introduction of this group did not affect the inhibitory activity of γ-carboline pharmacophore against acetyl- and butyrylcholinesterase.
作者简介
S. Bachurin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
														Email: Ustinov_51@mail.ru
				                					                																			                												                	俄罗斯联邦, 							1 Severny pr-d, Chernogolovka, Moscow Region, 142432						
A. Ustinov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
							编辑信件的主要联系方式.
							Email: Ustinov_51@mail.ru
				                					                																			                												                	俄罗斯联邦, 							1 Severny pr-d, Chernogolovka, Moscow Region, 142432						
I. Serkov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
														Email: Ustinov_51@mail.ru
				                					                																			                												                	俄罗斯联邦, 							1 Severny pr-d, Chernogolovka, Moscow Region, 142432						
A. Proshin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
														Email: Ustinov_51@mail.ru
				                					                																			                												                	俄罗斯联邦, 							1 Severny pr-d, Chernogolovka, Moscow Region, 142432						
N. Kovaleva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
														Email: Ustinov_51@mail.ru
				                					                																			                												                	俄罗斯联邦, 							1 Severny pr-d, Chernogolovka, Moscow Region, 142432						
N. Boltneva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
														Email: Ustinov_51@mail.ru
				                					                																			                												                	俄罗斯联邦, 							1 Severny pr-d, Chernogolovka, Moscow Region, 142432						
G. Makhaeva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
														Email: Ustinov_51@mail.ru
				                					                																			                												                	俄罗斯联邦, 							1 Severny pr-d, Chernogolovka, Moscow Region, 142432						
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