Email this article A new reaction of alkyl perchlorates with acetonitrile. Synthesis of N-alkylacetamides
- Authors: Yashin N.V.1,2, Averina E.B.1,2,3, Grishin Y.K.1, Kuznetsova T.S.1, Zefirov N.S.1,2
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Affiliations:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Issue: Vol 65, No 7 (2016)
- Pages: 1873-1875
- Section: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/238667
- DOI: https://doi.org/10.1007/s11172-016-1523-8
- ID: 238667
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Abstract
An ability of n-alkyl and 1-adamantylmethyl perchlorates to be converted to the corresponding N-alkylacetamides upon treatment with acetonitrile was demonstrated. This reaction is an example of Ritter-type reaction, which proceeds under exclusively mild conditions and requires no catalysis or special activation of reagents. N-Alkylacetamides were formed in quantitative yields in analytically pure form.
About the authors
N. V. Yashin
Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: elaver@org.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
E. B. Averina
Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: elaver@org.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432; 47 Leninsky prosp., Moscow, 119991
Yu. K. Grishin
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: elaver@org.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
T. S. Kuznetsova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: elaver@org.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
N. S. Zefirov
Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: elaver@org.chem.msu.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
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