Assembly of nitrogen-containing heterocycles initiated by the aza-Michael reaction
- Authors: Rulev A.Y.1
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Affiliations:
- A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 65, No 7 (2016)
- Pages: 1687-1699
- Section: Reviews
- URL: https://journals.rcsi.science/1066-5285/article/view/238507
- DOI: https://doi.org/10.1007/s11172-016-1497-6
- ID: 238507
Cite item
Abstract
The aza-Michael reaction is considered as the most popular method for the carbon–nitrogen bond formation and the shortest way to β-aminocarbonyl compounds, including β-amino acids and their derivatives. In many cases, conjugate addition of nitrogen-centered nucleophiles to the activated multiple bond triggers a series of cascade transformations being completed by the formation of heterocycles and analogs of natural compounds. The review summarizes the most important advances in the aza-Michael reaction-initiated synthesis of nitrogen-containing heterocycles from unsaturated ketones and enoates.
About the authors
A. Yu. Rulev
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: rulev@irioch.irk.ru
Russian Federation, 1 ul. Favorskogo, Irkutsk, 664033