Molecular design of multitarget neuroprotectors 3. Synthesis and bioactivity of tetrahydrocarbazole—aminoadamantane conjugates
- Authors: Sokolov V.B.1, Aksinenko A.Y.1, Goreva T.V.1, Epishina T.A.1, Grigor´ev V.V.1, Gabrel´yan A.V.1, Vinogradova D.V.1, Neganova M.E.1, Shevtsova E.F.1, Bachurin S.O.1
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Affiliations:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Issue: Vol 65, No 5 (2016)
- Pages: 1354-1359
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/238292
- DOI: https://doi.org/10.1007/s11172-016-1461-5
- ID: 238292
Cite item
Abstract
A synthetic approach to the design of new multitarget neuroprotectors consisting in combination of the tetrahydrocarbazole and aminoadamantane pharmacophore fragments through a 2-hydroxypropylene spacer upon the reaction of 9-oxiranylmethyl-2,3,4,9-tetrahydro-1H-carbazoles and aminoadamantanes, which affords 1-(adamantan-1-ylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ols, is proposed. The effect of the synthesized compounds on the neuronal NMDA receptors and the functional characteristics of rat liver mitochondria was studied.
About the authors
V. B. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Author for correspondence.
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
A. Yu. Aksinenko
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
T. V. Goreva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
T. A. Epishina
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
V. V. Grigor´ev
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
A. V. Gabrel´yan
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
D. V. Vinogradova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
M. E. Neganova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
E. F. Shevtsova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
S. O. Bachurin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432