电邮这篇文章 Molecular design of multitarget neuroprotectors 2. Synthesis and bioactivity of carbazole—γ-carboline conjugates
- 作者: Sokolov V.B.1, Aksinenko A.Y.1, Goreva T.V.1, Epishina T.A.1, Grigor´ev V.V.1, Gabrel´yan A.V.1, Vinogradova D.V.1, Dubova L.G.1, Shevtsov P.N.1, Shevtsova E.F.1, Bachurin S.O.1
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隶属关系:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- 期: 卷 65, 编号 5 (2016)
- 页面: 1346-1353
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/238275
- DOI: https://doi.org/10.1007/s11172-016-1460-6
- ID: 238275
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详细
Earlier unknown conjugates of carbazoles and γ-carbolines were obtained by the reaction of 3,6-substituted 9-oxiranylmethylcarbazoles and 2,8-substituted 2,3,4,5-tetrahydro-1H-pyrido-[4,3]indoles. The effects of synthesized 1-(9H-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5H-pyrido-[4,3-b]indol-5-yl)propan-2-ones and their hydrochlorides on neuronal NMDA receptors, polymerization of tubulin to form microtubules, and functional characteristics of rat liver mitochondria were studied.
作者简介
V. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
A. Aksinenko
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
T. Goreva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
T. Epishina
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
V. Grigor´ev
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
A. Gabrel´yan
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
D. Vinogradova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
L. Dubova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
P. Shevtsov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
E. Shevtsova
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
S. Bachurin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: alaks@ipac.ac.ru
俄罗斯联邦, 1 Severnyi proezd, Chernogolovka, Moscow region, 142432
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