Synthesis of (5 Z ,5´ Z )-3,3´-(alkane-α,ω-diyl)bis[5-(2-pyridylmethylidene)-2-methylthio-3,5-dihydro-4 H -imidazol-4-ones] and their coordination compounds with copper( ii )

K. I. Tishchenko; E. K. Beloglazkina; M. A. Proskurnin; A. G. Mazhuga; M. E. Muratova; D. A. Skvortsov; N. V. Zyk

doi:10.1007/s11172-016-1444-6

Synthesis of (5Z,5´Z)-3,3´-(alkane-α,ω-diyl)bis[5-(2-pyridylmethylidene)-2-methylthio-3,5-dihydro-4H-imidazol-4-ones] and their coordination compounds with copper(ii)

Authors: Tishchenko K.I.¹, Beloglazkina E.K.¹, Proskurnin M.A.¹, Mazhuga A.G.¹, Muratova M.E.¹, Skvortsov D.A.¹, Zyk N.V.¹
Affiliations:
1. Department of Chemistry, M. V. Lomonosov Moscow State University
Issue: Vol 65, No 5 (2016)
Pages: 1254-1259
Section: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/238098
DOI: https://doi.org/10.1007/s11172-016-1444-6
ID: 238098

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Abstract

A synthesis of copper(ii) coordination compounds based on the new tetradentate organic ligands from the series of (5Z,5´Z)-3,3´-(alkane-α,ω-diyl)bis[5-(2-pyridylmethylidene)-2-thio-3,5-dihydro-4H-imidazol-4-ones] was suggested. Biological activity of the copper(ii) coordination compounds was studied, their ability to inhibit telomerase activity was shown.