Email this article Synthesis and membrane protective activity of 4-alkoxymethyl-2,6-diisobornylphenols
- Authors: Buravlev E.V.1, Chukicheva I.Y.1, Shevchenko O.G.2, Suponitsky K.Y.3, Kutchin A.V.1
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Affiliations:
- Institute of Chemistry of Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- Institute of Biology of Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- Issue: Vol 65, No 5 (2016)
- Pages: 1232-1237
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/238071
- DOI: https://doi.org/10.1007/s11172-016-1440-x
- ID: 238071
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Abstract
Bromination of 2,6-diisobornyl-4-methylphenol gave the corresponding 4-bromomethyl derivative, whose reaction with alcohols resulted in 4-alkoxymethyl-2,6-diisobornylphenols. Their toxicity, membrane protective and antioxidant activity were tested using red blood cells of laboratory mice. The synthesized compounds do not exhibit cytotoxicity at the concentrations of 10 and 100 μmol L–1 and are characterized by high membrane protective and antioxidant activity in the concentrations of 1 and 10 μmol L–1.
About the authors
E. V. Buravlev
Institute of Chemistry of Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: eugeneburavlev@gmail.com
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167982
I. Yu. Chukicheva
Institute of Chemistry of Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: eugeneburavlev@gmail.com
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167982
O. G. Shevchenko
Institute of Biology of Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: eugeneburavlev@gmail.com
Russian Federation, 28 ul. Kommunisticheskaya, Syktyvkar, 167982
K. Yu. Suponitsky
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: eugeneburavlev@gmail.com
Russian Federation, 28 ul. Vavilova, Moscow, 119991
A. V. Kutchin
Institute of Chemistry of Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: eugeneburavlev@gmail.com
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167982
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