Email this article Synthesis and cytotoxic activity of usnic acid cyanoethyl derivatives
- Authors: Rakhmanova M.E.1,2, Luzina O.A.1, Pokrovskii M.A.2, Pokrovskii A.G.2, Salakhutdinov N.F.1,2
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Affiliations:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Novosibirsk State University
- Issue: Vol 65, No 2 (2016)
- Pages: 566-569
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237329
- DOI: https://doi.org/10.1007/s11172-016-1338-7
- ID: 237329
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Abstract
Cyanoethyl derivatives of usnic acid (natural lichen metabolite) were prepared. The reaction proceeded as a C-alkylation process via addition of two acrylonitrile molecules. Cytotoxic effect of the synthesized derivatives on the blood tumor cell lines was studied.
About the authors
M. E. Rakhmanova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: luzina@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
O. A. Luzina
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: luzina@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090
M. A. Pokrovskii
Novosibirsk State University
Email: luzina@nioch.nsc.ru
Russian Federation, 2 ul. Pirogova, Novosibirsk, 630090
A. G. Pokrovskii
Novosibirsk State University
Email: luzina@nioch.nsc.ru
Russian Federation, 2 ul. Pirogova, Novosibirsk, 630090
N. F. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: luzina@nioch.nsc.ru
Russian Federation, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
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