Synthesis, properties, and application of 4-nitrosemicarbazones
- 作者: Glukhacheva V.S.1, Il’yasov S.G.1, Sakovich G.V.1, Tolstikova T.G.2, Bryzgalov A.O.2, Pleshkova N.V.2
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隶属关系:
- Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- 期: 卷 65, 编号 2 (2016)
- 页面: 550-560
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237297
- DOI: https://doi.org/10.1007/s11172-016-1336-9
- ID: 237297
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详细
The studies of the condensation of 4-nitrosemicarbazide (4-NSC) with various aldehydes and ketones resulted in the development of an approach to the synthesis of N-nitrosemicarbazones, promising high-energy and biologically active compounds. Subsequent treatment with amines and alkalis led to the synthesis of water-soluble salts of nitrosemicarbazones, as well as the corresponding semicarbazones. The reaction of N,N′-diisopropyl- or N,N′-di-tert-butyl-1,2-ethanediimine with 4-nitrosemicarbazide led to the synthesis of glyoxal bis(nitrosemicarbazone) derivatives. A computer-aided screening using the PASS software showed a probability of high biological activity for the compounds obtained, whereas antiarrhythmic properties of camphor nitrosemicarbazone potassium salt were confirmed in experiments in rats.
作者简介
V. Glukhacheva
Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
Email: ipcet@mail.ru
俄罗斯联邦, 1 ul. Sotsialisticheskaya, Biisk Altaiskogo Kraya, 659322
S. Il’yasov
Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: ipcet@mail.ru
俄罗斯联邦, 1 ul. Sotsialisticheskaya, Biisk Altaiskogo Kraya, 659322
G. Sakovich
Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
Email: ipcet@mail.ru
俄罗斯联邦, 1 ul. Sotsialisticheskaya, Biisk Altaiskogo Kraya, 659322
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: ipcet@mail.ru
俄罗斯联邦, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090
A. Bryzgalov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: ipcet@mail.ru
俄罗斯联邦, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090
N. Pleshkova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: ipcet@mail.ru
俄罗斯联邦, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090
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