Synthesis, properties, and application of 4-nitrosemicarbazones
- Авторы: Glukhacheva V.S.1, Il’yasov S.G.1, Sakovich G.V.1, Tolstikova T.G.2, Bryzgalov A.O.2, Pleshkova N.V.2
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							Учреждения: 
							- Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
 
- Выпуск: Том 65, № 2 (2016)
- Страницы: 550-560
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237297
- DOI: https://doi.org/10.1007/s11172-016-1336-9
- ID: 237297
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Аннотация
The studies of the condensation of 4-nitrosemicarbazide (4-NSC) with various aldehydes and ketones resulted in the development of an approach to the synthesis of N-nitrosemicarbazones, promising high-energy and biologically active compounds. Subsequent treatment with amines and alkalis led to the synthesis of water-soluble salts of nitrosemicarbazones, as well as the corresponding semicarbazones. The reaction of N,N′-diisopropyl- or N,N′-di-tert-butyl-1,2-ethanediimine with 4-nitrosemicarbazide led to the synthesis of glyoxal bis(nitrosemicarbazone) derivatives. A computer-aided screening using the PASS software showed a probability of high biological activity for the compounds obtained, whereas antiarrhythmic properties of camphor nitrosemicarbazone potassium salt were confirmed in experiments in rats.
Об авторах
V. Glukhacheva
Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
														Email: ipcet@mail.ru
				                					                																			                												                	Россия, 							1 ul. Sotsialisticheskaya, Biisk Altaiskogo Kraya, 659322						
S. Il’yasov
Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
							Автор, ответственный за переписку.
							Email: ipcet@mail.ru
				                					                																			                												                	Россия, 							1 ul. Sotsialisticheskaya, Biisk Altaiskogo Kraya, 659322						
G. Sakovich
Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences
														Email: ipcet@mail.ru
				                					                																			                												                	Россия, 							1 ul. Sotsialisticheskaya, Biisk Altaiskogo Kraya, 659322						
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
														Email: ipcet@mail.ru
				                					                																			                												                	Россия, 							9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090						
A. Bryzgalov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
														Email: ipcet@mail.ru
				                					                																			                												                	Россия, 							9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090						
N. Pleshkova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
														Email: ipcet@mail.ru
				                					                																			                												                	Россия, 							9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090						
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