Email this article Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine
- Authors: Pavelyev R.S.1, Khairullina R.R.1, Koshkin S.A.1, Iksanova A.G.1, Lodochnikova O.A.2, Khaertdinov N.N.1, Sitdikova G.F.1, Safina A.F.1, Aleksandrova E.G.1, Ziganshina L.E.1, Shtyrlin Y.G.1
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Affiliations:
- Kazan (Volga Region) Federal University
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
- Issue: Vol 65, No 2 (2016)
- Pages: 519-531
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/237242
- DOI: https://doi.org/10.1007/s11172-016-1332-0
- ID: 237242
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Abstract
An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadrenergic properties of some synthesized compounds were studied on the models in situ and in vivo.
About the authors
R. S. Pavelyev
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
R. R. Khairullina
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
S. A. Koshkin
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
A. G. Iksanova
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
O. A. Lodochnikova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 8 ul. Akad. Arbuzova, Kazan, 420088
N. N. Khaertdinov
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
G. F. Sitdikova
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
A. F. Safina
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
E. G. Aleksandrova
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
L. E. Ziganshina
Kazan (Volga Region) Federal University
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
Yu. G. Shtyrlin
Kazan (Volga Region) Federal University
Author for correspondence.
Email: Yurii.Shtyrlin@gmail.com
Russian Federation, 18 ul. Kremlevskaya, Kazan, 420008
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