Preparation and Biodistribution of  99 m  Tc-Trazodone as a Brain Imaging Probe

H. A. El-Sabagh; H. M. Talaat; M. S. A. Abdel-Mottaleb

doi:10.1134/S1066362219010144

Preparation and Biodistribution of ^99mTc-Trazodone as a Brain Imaging Probe

Authors: El-Sabagh H.A.¹, Talaat H.M.¹, Abdel-Mottaleb M.S.²
Affiliations:
1. Hot Laboratories Centre
2. Department of Chemistry, Faculty of Science
Issue: Vol 61, No 1 (2019)
Pages: 93-98
Section: Article
URL: https://journals.rcsi.science/1066-3622/article/view/224945
DOI: https://doi.org/10.1134/S1066362219010144
ID: 224945

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Abstract
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Abstract

Trazodone was labeled with ^99mTc by indirect method. More than 97% radiochemical yield was reached under the following optimized conditions: 100 µg of Trazodone, pH 7, 10 mg of glucoheptonate, 35 µg of stannous chloride, 185 MBq of ^99mTc eluate, 20 min, room temperature. The in vitro stability and also the retention of the complex in the brain tissue allow the use of this complex as a potential brain imaging agent.