Characteristics of receptor- and transducer-coupled activation of the intracellular signalling in sensory neuron revealed by atomic force microscopy
- Авторы: Khalisov M.1,2, Penniyaynen V.1, Esikova N.3, Ankudinov A.2,4, Krylov B.1
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Учреждения:
- Pavlov Institute of Physiology
- St. Petersburg National Research University of Information Technologies, Mechanics, and Optics
- Institute for Analytical Instrumentation
- Ioffe Physical Technical Institute
- Выпуск: Том 43, № 1 (2017)
- Страницы: 85-87
- Раздел: Article
- URL: https://journals.rcsi.science/1063-7850/article/view/202564
- DOI: https://doi.org/10.1134/S1063785017010072
- ID: 202564
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Аннотация
The mechanical properties of sensory neurons upon activation of intracellular cascade processes by comenic acid binding to a membrane opioid-like receptor (receptor-coupled), as well as a very low (endogenous) concentration of ouabain (transducer-coupled), have been investigated. Using atomic force microscopy, it is established that exposure to ouabain, in contrast to the impact of comenic acid, leads to a hardening of the neuron soma. This suggests that the receptor-coupled signal transmission to the cell genome is carried out through mechanisms that are different from the transducer-coupled signal pathways.
Об авторах
M. Khalisov
Pavlov Institute of Physiology; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics
Email: alexander.ankudinov@mail.ioffe.ru
Россия, St. Petersburg, 199034; St. Petersburg, 197101
V. Penniyaynen
Pavlov Institute of Physiology
Email: alexander.ankudinov@mail.ioffe.ru
Россия, St. Petersburg, 199034
N. Esikova
Institute for Analytical Instrumentation
Email: alexander.ankudinov@mail.ioffe.ru
Россия, St. Petersburg, 198095
A. Ankudinov
St. Petersburg National Research University of Information Technologies, Mechanics, and Optics; Ioffe Physical Technical Institute
Автор, ответственный за переписку.
Email: alexander.ankudinov@mail.ioffe.ru
Россия, St. Petersburg, 197101; St. Petersburg, 194021
B. Krylov
Pavlov Institute of Physiology
Email: alexander.ankudinov@mail.ioffe.ru
Россия, St. Petersburg, 199034