Probing Mechanical Characteristics of Living Fibroblasts via Atomic Force Microscopy

K. I. Timoshchuk; M. M. Khalisov; V. A. Penniyaynen; B. V. Krylov; A. V. Ankudinov

doi:10.1134/S1063785019090293

Probing Mechanical Characteristics of Living Fibroblasts via Atomic Force Microscopy

Autores: Timoshchuk K.¹, Khalisov M.¹, Penniyaynen V.¹, Krylov B.¹, Ankudinov A.²
Afiliações:
1. Pavlov Institute of Physiology, Russian Academy of Sciences
2. Ioffe Physical Technical Institute, Russian Academy of Sciences
Edição: Volume 45, Nº 9 (2019)
Páginas: 947-950
Seção: Article
URL: https://journals.rcsi.science/1063-7850/article/view/208435
DOI: https://doi.org/10.1134/S1063785019090293
ID: 208435

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Atomic force microscopy (AFM) measurements have revealed hardening of intact fibroblasts after treatment with colchicine. The reliability of AFM measurements was confirmed by the identification of cells the lateral response of which to indentation did not disturb the normal force contribution. AFM data on the mechanical characteristics of such cells admit an unambiguous interpretation.