Email this article Probing Mechanical Characteristics of Living Fibroblasts via Atomic Force Microscopy
- Authors: Timoshchuk K.I.1, Khalisov M.M.1, Penniyaynen V.A.1, Krylov B.V.1, Ankudinov A.V.2
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Affiliations:
- Pavlov Institute of Physiology, Russian Academy of Sciences
- Ioffe Physical Technical Institute, Russian Academy of Sciences
- Issue: Vol 45, No 9 (2019)
- Pages: 947-950
- Section: Article
- URL: https://journals.rcsi.science/1063-7850/article/view/208435
- DOI: https://doi.org/10.1134/S1063785019090293
- ID: 208435
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Abstract
Atomic force microscopy (AFM) measurements have revealed hardening of intact fibroblasts after treatment with colchicine. The reliability of AFM measurements was confirmed by the identification of cells the lateral response of which to indentation did not disturb the normal force contribution. AFM data on the mechanical characteristics of such cells admit an unambiguous interpretation.
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About the authors
K. I. Timoshchuk
Pavlov Institute of Physiology, Russian Academy of Sciences
Email: alexander.ankudinov@mail.ioffe.ru
Russian Federation, St. Petersburg, 199034
M. M. Khalisov
Pavlov Institute of Physiology, Russian Academy of Sciences
Email: alexander.ankudinov@mail.ioffe.ru
Russian Federation, St. Petersburg, 199034
V. A. Penniyaynen
Pavlov Institute of Physiology, Russian Academy of Sciences
Email: alexander.ankudinov@mail.ioffe.ru
Russian Federation, St. Petersburg, 199034
B. V. Krylov
Pavlov Institute of Physiology, Russian Academy of Sciences
Email: alexander.ankudinov@mail.ioffe.ru
Russian Federation, St. Petersburg, 199034
A. V. Ankudinov
Ioffe Physical Technical Institute, Russian Academy of Sciences
Author for correspondence.
Email: alexander.ankudinov@mail.ioffe.ru
Russian Federation, St. Petersburg, 194021
