Nonlinear Dynamics of Firing Activity Patterns of Nociceptive Neurons during Management of Damaging Pain Stimulation
- Authors: Dik O.E.1
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Affiliations:
- Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 64, No 3 (2019)
- Pages: 427-435
- Section: Biomedical Physics
- URL: https://journals.rcsi.science/1063-7842/article/view/203153
- DOI: https://doi.org/10.1134/S1063784219030101
- ID: 203153
Cite item
Abstract
A bifurcation analysis of a nociceptive neuron model was performed to study how the firing activity pattern changes when an antinociceptive response to damaging pain stimulation arises in rat dorsal ganglia. Ectopic train activity was found to arise in the model. Suppression of train activity was demonstrated to proceed solely through modification of the activation gating structure of the NaV1.8 slow sodium channel in response to comenic acid, which exerts an analgesic effect and is an active ingredient of the new nonopioid analgesic Anoceptin.
About the authors
O. E. Dik
Pavlov Institute of Physiology, Russian Academy of Sciences
Author for correspondence.
Email: dickviola@gmail.com
Russian Federation, St. Petersburg, 199034