Nonlinear Dynamics of Firing Activity Patterns of Nociceptive Neurons during Management of Damaging Pain Stimulation
- 作者: Dik O.1
-
隶属关系:
- Pavlov Institute of Physiology, Russian Academy of Sciences
- 期: 卷 64, 编号 3 (2019)
- 页面: 427-435
- 栏目: Biomedical Physics
- URL: https://journals.rcsi.science/1063-7842/article/view/203153
- DOI: https://doi.org/10.1134/S1063784219030101
- ID: 203153
如何引用文章
详细
A bifurcation analysis of a nociceptive neuron model was performed to study how the firing activity pattern changes when an antinociceptive response to damaging pain stimulation arises in rat dorsal ganglia. Ectopic train activity was found to arise in the model. Suppression of train activity was demonstrated to proceed solely through modification of the activation gating structure of the NaV1.8 slow sodium channel in response to comenic acid, which exerts an analgesic effect and is an active ingredient of the new nonopioid analgesic Anoceptin.
作者简介
O. Dik
Pavlov Institute of Physiology, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: dickviola@gmail.com
俄罗斯联邦, St. Petersburg, 199034