Biologically Active Hybrid Nanosystems Based on Zero-Valent Selenium Nanoparticles, Biocompatible Polymers, and Polyelectrolitic Complex

Abstract

The molecular-conformal, morphological, and kinetic characteristics of selenium-containing nanosystems (NSs) based of biocompatible polymer matrices of different origins modified Se⁰ nanoparticles for the Se⁰ : polymer mass ratio ν = 0.1 have been analyzed using static and dynamic light scattering methods, UV spectroscopy, flow birefringence, and atomic force and transmission electron microscopies. We have determined the rate constants for the formation of selenium-containing NSs, the size characteristics of the corresponding nanostructures, as well as their shape, molecular mass, and density. It is found that isolated dense spherical polymolecular selenium-containing nanostructures are formed in the aqueous solution. Our results can be used as the physicochemical foundation for the modification of polymer materials with clearly manifested physiological activity by biogenic elements in the zero-valent form.