On DNA Motions under Action of Enzymes of Different Types. I

详细

Different types of enzymes in rotational macromolecular motors of living cells are presented based on the data in the literature. Particular attention has been given to the restriction–modification enzymes and helicases, in which conformational changes in sites are physical reasons of linear motions and rotation of DNA molecules (caused by polar forces). It is shown that the structure and functioning of enzymes, similar to those in chiral smectic C-type liquid crystals, can be described within the formalism of generalized forces and currents. These forces include the membrane electrochemical gradient, the velocity of rotor mechanical motion, and the measure of change in free energy in the “fuel” adenosine triphosphate molecule.