Experimental and theoretical study of the transport of silver nanoparticles at their prolonged administration into a mammal organism

Resumo

The transport of silver nanoparticles in the organism of laboratory animals has been investigated. A mathematical model of the biokinetics of prolonged administration of nonmetabolizable and nonaglomerating pharmaceutical preparations is proposed, and its analytical solution is found. Based on the experimental data on the prolonged introduction and excretion of colloidal silver nanoparticles and the numerical approximation of the solutions to the equations for the proposed model, time dependences of the silver mass content in brain and blood are obtained and some other important biokinetic parameters are determined. It is concluded that both chronic¹ and subchronic² peroral application of these nanoparticles as an biologically active additive or antiseptic is potentially dangerous.