Experimental and theoretical study of the transport of silver nanoparticles at their prolonged administration into a mammal organism
- Authors: Antsiferova A.A.1,2, Buzulukov Y.P.1,2, Kashkarov P.K.1,3,2, Kovalchuk M.V.1,3,4
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Affiliations:
- National Research Centre “Kurchatov Institute”
- Moscow Institute of Physics and Technology
- Moscow State University
- St. Petersburg State University
- Issue: Vol 61, No 6 (2016)
- Pages: 1020-1026
- Section: Nanomaterials and Ceramics
- URL: https://journals.rcsi.science/1063-7745/article/view/190439
- DOI: https://doi.org/10.1134/S1063774516060031
- ID: 190439
Cite item
Abstract
The transport of silver nanoparticles in the organism of laboratory animals has been investigated. A mathematical model of the biokinetics of prolonged administration of nonmetabolizable and nonaglomerating pharmaceutical preparations is proposed, and its analytical solution is found. Based on the experimental data on the prolonged introduction and excretion of colloidal silver nanoparticles and the numerical approximation of the solutions to the equations for the proposed model, time dependences of the silver mass content in brain and blood are obtained and some other important biokinetic parameters are determined. It is concluded that both chronic1 and subchronic2 peroral application of these nanoparticles as an biologically active additive or antiseptic is potentially dangerous.
About the authors
A. A. Antsiferova
National Research Centre “Kurchatov Institute”; Moscow Institute of Physics and Technology
Author for correspondence.
Email: antsiferova_aa@nrcki.ru
Russian Federation, Moscow, 123182; Dolgoprudnyi, Moscow oblast, 141700
Yu. P. Buzulukov
National Research Centre “Kurchatov Institute”; Moscow Institute of Physics and Technology
Email: antsiferova_aa@nrcki.ru
Russian Federation, Moscow, 123182; Dolgoprudnyi, Moscow oblast, 141700
P. K. Kashkarov
National Research Centre “Kurchatov Institute”; Moscow State University; Moscow Institute of Physics and Technology
Email: antsiferova_aa@nrcki.ru
Russian Federation, Moscow, 123182; Moscow; Dolgoprudnyi, Moscow oblast, 141700
M. V. Kovalchuk
National Research Centre “Kurchatov Institute”; Moscow State University; St. Petersburg State University
Email: antsiferova_aa@nrcki.ru
Russian Federation, Moscow, 123182; Moscow; St. Petersburg, 199034