Email this article Absolute Configuration of Andrographolide and Its Proliferation of Osteoblast Cell Lines
- Authors: Chantrapromma S.1, Boonnak N.2, Pitakpornpreecha T.3, Yordthong T.3, Chidan Kumar C.S.4,5, Fun H.K.5
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Affiliations:
- Department of Chemistry, Faculty of Science
- Department of Basic Science and Mathematics, Faculty of Science
- Department of Biochemistry, Faculty of Science
- Department of Engineering Chemistry, Vidya Vikas Institute of Engineering and Technology
- X-ray Crystallography Unit, School of Physics
- Issue: Vol 63, No 3 (2018)
- Pages: 412-417
- Section: Structure of Organic Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/192518
- DOI: https://doi.org/10.1134/S1063774518030069
- ID: 192518
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Abstract
Andrographolide, C20H30O5, is a labdane diterpenoid which was isolated from the leave of Andrographis paniculata. Its crystal structure is determined by single crystal X-ray diffraction: monoclinic, sp. gr. P21, Z = 2. Absolute configuration is determined by the refinement of the Flack parameter to 0.21(19). In the crystal, molecules are linked by O–H···O hydrogen bonds and C–H···O interactions into two dimensional network parallel to the (001) plane. Its proliferation of osteoblast cell lines is reported.
About the authors
S. Chantrapromma
Department of Chemistry, Faculty of Science
Author for correspondence.
Email: suchada_3p@hotmail.com
Thailand, Hat-Yai, Songkhla, 90112
N. Boonnak
Department of Basic Science and Mathematics, Faculty of Science
Email: suchada_3p@hotmail.com
Thailand, Songkhla, 90000
T. Pitakpornpreecha
Department of Biochemistry, Faculty of Science
Email: suchada_3p@hotmail.com
Thailand, Hat-Yai, Songkhla, 90112
T. Yordthong
Department of Biochemistry, Faculty of Science
Email: suchada_3p@hotmail.com
Thailand, Hat-Yai, Songkhla, 90112
C. S. Chidan Kumar
Department of Engineering Chemistry, Vidya Vikas Institute of Engineering and Technology; X-ray Crystallography Unit, School of Physics
Email: suchada_3p@hotmail.com
India, Karnataka, Mysuru, 570028; USM, Penang, 11800
H. K. Fun
X-ray Crystallography Unit, School of Physics
Email: suchada_3p@hotmail.com
Malaysia, USM, Penang, 11800
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