The Influence of an Extract from the Marine Brown Alga Sargassum pallidum on the Metabolic Reactions in the Liver under Experimental Toxic Hepatitis


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

This study explores the influence of an extract enriched with polyphenol substances obtained from the brown alga Sargassum pallidum and the effect of the Legalon commercial reference preparation on the biochemical indices of the blood at acute hepatic injury induced in rats with carbon tetrachloride (CTC). Administration of S. pallidum extract exhibited a pronounced antioxidant and hepatoprotective effect revealed in reduction of alanine aminotransferase (AlAT) activity in blood plasm, in normalization of superoxide dismutase activity and reduced glutathione contents, of the level of lipid peroxidation, and the liver antiradical activity. We observed recovery of lipid metabolism and elimination of liver fatty infiltration. The S. pallidum extract was as effective as the reference Legalon hepatoprotector and even surpassed it in its ability to restore the phospholipid metabolism. In our opinion, this hepatoprotective effect of S. pallidum extract is associated with the action of polyphenols contained in brown algae, that is, phlorotannins, which are highly active antioxidants and restore the liver metabolic reactions after toxic hepatic injury with CTC.

Sobre autores

V. Sprygin

Il’ichev Pacific Oceanological Institute

Autor responsável pela correspondência
Email: vsprygin@poi.dvo.ru
Rússia, Vladivostok, 690041

N. Kushnerova

Il’ichev Pacific Oceanological Institute

Email: vsprygin@poi.dvo.ru
Rússia, Vladivostok, 690041

S. Fomenko

Il’ichev Pacific Oceanological Institute

Email: vsprygin@poi.dvo.ru
Rússia, Vladivostok, 690041

E. Drugova

Il’ichev Pacific Oceanological Institute

Email: vsprygin@poi.dvo.ru
Rússia, Vladivostok, 690041

L. Lesnikova

Il’ichev Pacific Oceanological Institute

Email: vsprygin@poi.dvo.ru
Rússia, Vladivostok, 690041

V. Merzlyakov

Il’ichev Pacific Oceanological Institute

Email: vsprygin@poi.dvo.ru
Rússia, Vladivostok, 690041

T. Momot

Far Eastern Federal University; Zhirmunsky Institute of Marine Biology

Email: vsprygin@poi.dvo.ru
Rússia, Vladivostok, 690950; Vladivostok, 690041

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Pleiades Publishing, Ltd., 2017