Exogenous iron redistribution between brain and liver after administering  57 Fe 3 O 4  ferrofluid to a rat brain ventricle

R. R. Gabbasov; V. M. Cherepanov; M. A. Chuev; I. N. Mishchenko; D. M. Polikarpov; N. A. Loginova; E. V. Loseva; M. P. Nikitin; V. Y. Panchenko

doi:10.3103/S1062873817070127

Exogenous iron redistribution between brain and liver after administering ⁵⁷Fe₃O₄ ferrofluid to a rat brain ventricle

作者: Gabbasov R.R.¹, Cherepanov V.M.¹, Chuev M.A.¹^,2, Mishchenko I.N.¹^,2, Polikarpov D.M.¹^,3, Loginova N.A.⁴, Loseva E.V.⁴, Nikitin M.P.⁵, Panchenko V.Y.¹
隶属关系:
1. National Research Center Kurchatov Institute
2. Institute of Physics and Technology
3. Macquarie University
4. Institute of Higher Nervous Activity and Neurophysiology
5. Moscow Institute of Physics and Technology
期: 卷 81, 编号 7 (2017)
页面: 788-792
栏目: Article
URL: https://journals.rcsi.science/1062-8738/article/view/185117
DOI: https://doi.org/10.3103/S1062873817070127
ID: 185117

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The natural excretion of ⁵⁷Fe enriched magnetic nanoparticles from a rat’s brain through its blood–brain barrier is studied. Dextran-coated iron oxide nanoparticles are transcranially injected into the rat’s brain ventricle. The injected nanoparticles undergo biotransformation into iron-containing proteins distributed over the brain tissues, while the exogenous iron transported from the brain to other organs is eliminated from the body over time.