Email this article Exogenous iron redistribution between brain and liver after administering 57Fe3O4 ferrofluid to a rat brain ventricle
- Authors: Gabbasov R.R.1, Cherepanov V.M.1, Chuev M.A.1,2, Mishchenko I.N.1,2, Polikarpov D.M.1,3, Loginova N.A.4, Loseva E.V.4, Nikitin M.P.5, Panchenko V.Y.1
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Affiliations:
- National Research Center Kurchatov Institute
- Institute of Physics and Technology
- Macquarie University
- Institute of Higher Nervous Activity and Neurophysiology
- Moscow Institute of Physics and Technology
- Issue: Vol 81, No 7 (2017)
- Pages: 788-792
- Section: Article
- URL: https://journals.rcsi.science/1062-8738/article/view/185117
- DOI: https://doi.org/10.3103/S1062873817070127
- ID: 185117
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Abstract
The natural excretion of 57Fe enriched magnetic nanoparticles from a rat’s brain through its blood–brain barrier is studied. Dextran-coated iron oxide nanoparticles are transcranially injected into the rat’s brain ventricle. The injected nanoparticles undergo biotransformation into iron-containing proteins distributed over the brain tissues, while the exogenous iron transported from the brain to other organs is eliminated from the body over time.
About the authors
R. R. Gabbasov
National Research Center Kurchatov Institute
Author for correspondence.
Email: gabbasov_rr@nrchi.ru
Russian Federation, Moscow, 123182
V. M. Cherepanov
National Research Center Kurchatov Institute
Email: gabbasov_rr@nrchi.ru
Russian Federation, Moscow, 123182
M. A. Chuev
National Research Center Kurchatov Institute; Institute of Physics and Technology
Email: gabbasov_rr@nrchi.ru
Russian Federation, Moscow, 123182; Moscow, 117218
I. N. Mishchenko
National Research Center Kurchatov Institute; Institute of Physics and Technology
Email: gabbasov_rr@nrchi.ru
Russian Federation, Moscow, 123182; Moscow, 117218
D. M. Polikarpov
National Research Center Kurchatov Institute; Macquarie University
Email: gabbasov_rr@nrchi.ru
Russian Federation, Moscow, 123182; Sydney, NSW, 2109
N. A. Loginova
Institute of Higher Nervous Activity and Neurophysiology
Email: gabbasov_rr@nrchi.ru
Russian Federation, Moscow, 117485
E. V. Loseva
Institute of Higher Nervous Activity and Neurophysiology
Email: gabbasov_rr@nrchi.ru
Russian Federation, Moscow, 117485
M. P. Nikitin
Moscow Institute of Physics and Technology
Email: gabbasov_rr@nrchi.ru
Russian Federation, Dolgoprudny, Moscow oblast, 141701
V. Y. Panchenko
National Research Center Kurchatov Institute
Email: gabbasov_rr@nrchi.ru
Russian Federation, Moscow, 123182
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