Email this article Localizing the Nanodeformation Impact of Magnetic Nanoparticles on Macromolecular Objects by Physical and Biochemical Means
- Authors: Golovin Y.I.1,2,3,4, Zhigachev A.O.1, Klyachko N.L.2,3, Kabanov A.V.2,4
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Affiliations:
- Research Institute Nanotechnologies and Nanomaterials
- Moscow State University
- National University of Science and Technology MISiS
- University of North Carolina
- Issue: Vol 82, No 9 (2018)
- Pages: 1073-1078
- Section: Article
- URL: https://journals.rcsi.science/1062-8738/article/view/186118
- DOI: https://doi.org/10.3103/S1062873818090095
- ID: 186118
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Abstract
A new magnetomechanical approach in biomedicine is described. It is based on the rotational oscillations of magnetic nanoparticles (MNPs) in a non-heating magnetic field (MF) at frequencies of 0.1–1000 Hz. Nanodeformations induced in associated macromolecules can be used for selective control of their properties. Models of local molecular effects are presented, and the possibility of inducing biochemical responses through the deformation of biomembranes and membrane structures is assessed. A way of macroscopically limiting the MNP activation volume in a gradient MF is proposed.
About the authors
Yu. I. Golovin
Research Institute Nanotechnologies and Nanomaterials; Moscow State University; National University of Science and Technology MISiS; University of North Carolina
Author for correspondence.
Email: nano@tsutmb.ru
Russian Federation, Tambov, 392000; Moscow, 119991; Moscow, 119049; Chapel Hill, 27599
Al. O. Zhigachev
Research Institute Nanotechnologies and Nanomaterials
Email: nano@tsutmb.ru
Russian Federation, Tambov, 392000
N. L. Klyachko
Moscow State University; National University of Science and Technology MISiS
Email: nano@tsutmb.ru
Russian Federation, Moscow, 119991; Moscow, 119049
A. V. Kabanov
Moscow State University; University of North Carolina
Email: nano@tsutmb.ru
Russian Federation, Moscow, 119991; Chapel Hill, 27599
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