Hypoxia during mammalian preimplantation development: Extreme circumstance vs. typical environment


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The given paper summarizes the data on the early mammalian embryo development in culture media containing low oxygen concentration. Experimental results on in vitro modeling the hypoxia for preimplantation development are reviewed. Hypoxic conditions were shown to be available in the female reproductive tract of different mammalian species. The estimation of the embryo developing in vitro exhibits that lower oxygen level in culture media improves embryonic quality.

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A. Pogorelov

Institute of Theoretical and Experimental Biophysics

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Email: agpogorelov@rambler.ru
俄罗斯联邦, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

A. Smirnov

Institute of Theoretical and Experimental Biophysics

Email: agpogorelov@rambler.ru
俄罗斯联邦, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

V. Pogorelova

Institute of Theoretical and Experimental Biophysics

Email: agpogorelov@rambler.ru
俄罗斯联邦, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

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