Ethanol as a Possible Modifier of Acute Radiation Lesions of the Brain
- Autores: Fyodorov V.1, Ushakov I.1,2, Shalnova G.1
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Afiliações:
- Russian State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
- Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of Emergency Situations of the Russian Federation
- Edição: Volume 46, Nº 11 (2019)
- Páginas: 1533-1539
- Seção: Materials from the International Conference “Radiation Exposure-Related Problems of Chemical Protection and Repair” (Dubna, 30–31 May, 2018)
- URL: https://journals.rcsi.science/1062-3590/article/view/183386
- DOI: https://doi.org/10.1134/S1062359019110128
- ID: 183386
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Resumo
Cerebral effects were studied in experiments on rats exposed to acute γ-radiation of the head at cerebral doses, with previous or subsequent administration of different ethanol doses. Both factors cause similar changes in neurological symptoms and neuromorphological effects. Ethanol before irradiation did not significantly modify the state of neurons, but caused the appearance of synapses degenerating via filament type. After irradiation, ethanol at the threshold dose did not change and at a large tranquilizing dose slightly increased radiation changes in neurons and synapses. The effects of radio-modification depended on the dose of ethanol and the time of its administration.
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Sobre autores
V. Fyodorov
Russian State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Autor responsável pela correspondência
Email: fedor.vp@mail.ru
Rússia, Moscow, 123098
I. Ushakov
Russian State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of Emergency Situations of the Russian Federation
Email: fedor.vp@mail.ru
Rússia, Moscow, 123098; Saint-Petersburg, 197082
G. Shalnova
Russian State Research Center—Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: fedor.vp@mail.ru
Rússia, Moscow, 123098