Cytogenetic Activity of Gold Nanoparticles in Germ and Somatic Cells of 129 Mice with a Nonsense Mutation in the DNA Polymerase Iota Gene
- Авторлар: Mudzhiri N.1,2, Zakhidov S.1, Rudoy V.3, Dement’eva O.3, Makarov A.4, Makarova I.5, Zelenina I.1, Andreeva L.5, Marshak T.2
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Мекемелер:
- Faculty of Biology
- Koltzov Institute of Developmental Biology
- Frumkin Institute of Physical Chemistry and Electrochemistry
- Higher School of Economics National Research University
- Institute of Molecular Genetics
- Шығарылым: Том 45, № 2 (2018)
- Беттер: 119-125
- Бөлім: Developmental Biology
- URL: https://journals.rcsi.science/1062-3590/article/view/182721
- DOI: https://doi.org/10.1134/S1062359018020085
- ID: 182721
Дәйексөз келтіру
Аннотация
In this study, we investigated the cytogenetic effects of single and quadruple exposure of spermatogenic cells and hepatocytes of 129 mice, which have a mutation in the gene that encodes DNA polymerase iota, to ultrasmall gold nanoparticles (GNPs). The combined effects of GNPs and chemical mutagen dipin were evaluated. In all cases, except for the experiment with the quadruple GNP injection, we observed a slight, statistically nonsignificant increase in the frequency of round spermatids with micronuclei compared to the negative control (saline). It is established that, in the intact liver of 129 mice, in all variants of the experiment, GNPs behaved as a potentially cytotoxic agent, as evidenced by the decrease in the frequency of the micronucleated hepatocytes.
Авторлар туралы
N. Mudzhiri
Faculty of Biology; Koltzov Institute of Developmental Biology
Email: 4361.idb@bk.ru
Ресей, Moscow, 119991; Moscow, 119334
S. Zakhidov
Faculty of Biology
Email: 4361.idb@bk.ru
Ресей, Moscow, 119991
V. Rudoy
Frumkin Institute of Physical Chemistry and Electrochemistry
Email: 4361.idb@bk.ru
Ресей, Moscow, 119071
O. Dement’eva
Frumkin Institute of Physical Chemistry and Electrochemistry
Email: 4361.idb@bk.ru
Ресей, Moscow, 119071
A. Makarov
Higher School of Economics National Research University
Email: 4361.idb@bk.ru
Ресей, Moscow, 101000
I. Makarova
Institute of Molecular Genetics
Email: 4361.idb@bk.ru
Ресей, Moscow, 123182
I. Zelenina
Faculty of Biology
Email: 4361.idb@bk.ru
Ресей, Moscow, 119991
L. Andreeva
Institute of Molecular Genetics
Email: 4361.idb@bk.ru
Ресей, Moscow, 123182
T. Marshak
Koltzov Institute of Developmental Biology
Хат алмасуға жауапты Автор.
Email: 4361.idb@bk.ru
Ресей, Moscow, 119334