The Protective Effect of Semax in a Model of Stress-Induced Impairment of Memory and Behavior in White Rats
- Authors: Glazova N.Y.1, Sebentsova E.A.1, Manchenko D.M.2, Andreeva L.A.1, Dergunova L.V.1, Levitskaya N.G.1,2, Limborska S.A.1, Myasoedov N.F.1
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Affiliations:
- Institute of Molecular Genetics
- Faculty of Biology
- Issue: Vol 45, No 4 (2018)
- Pages: 394-399
- Section: Animal and Human Physiology
- URL: https://journals.rcsi.science/1062-3590/article/view/182773
- DOI: https://doi.org/10.1134/S1062359018040040
- ID: 182773
Cite item
Abstract
The effect of acute restrained stress on cognitive functions and anxiety-like behavior in white rats has been studied; furthermore, the influence of the fragment ACTH(4–10) analog Semax on the stress effects was evaluated. It was shown that stress exposure leads to impaired retention of previously acquired food-motivated maze task as well as reduced anxiety-like behavior in the elevated plus maze in rats. Preliminary intraperitonial administration of Semax (0.1 mg/kg) attenuates cognitive impairment caused by acute restrained stress, but it does not affect stress-induced changes in anxiety.
About the authors
N. Yu. Glazova
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
Russian Federation, Moscow, 123182
E. A. Sebentsova
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
Russian Federation, Moscow, 123182
D. M. Manchenko
Faculty of Biology
Email: nglevitskaya@gmail.com
Russian Federation, Moscow, 119992
L. A. Andreeva
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
Russian Federation, Moscow, 123182
L. V. Dergunova
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
Russian Federation, Moscow, 123182
N. G. Levitskaya
Institute of Molecular Genetics; Faculty of Biology
Author for correspondence.
Email: nglevitskaya@gmail.com
Russian Federation, Moscow, 123182; Moscow, 119992
S. A. Limborska
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
Russian Federation, Moscow, 123182
N. F. Myasoedov
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
Russian Federation, Moscow, 123182