The Protective Effect of Semax in a Model of Stress-Induced Impairment of Memory and Behavior in White Rats
- 作者: Glazova N.1, Sebentsova E.1, Manchenko D.2, Andreeva L.1, Dergunova L.1, Levitskaya N.1,2, Limborska S.1, Myasoedov N.1
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隶属关系:
- Institute of Molecular Genetics
- Faculty of Biology
- 期: 卷 45, 编号 4 (2018)
- 页面: 394-399
- 栏目: Animal and Human Physiology
- URL: https://journals.rcsi.science/1062-3590/article/view/182773
- DOI: https://doi.org/10.1134/S1062359018040040
- ID: 182773
如何引用文章
详细
The effect of acute restrained stress on cognitive functions and anxiety-like behavior in white rats has been studied; furthermore, the influence of the fragment ACTH(4–10) analog Semax on the stress effects was evaluated. It was shown that stress exposure leads to impaired retention of previously acquired food-motivated maze task as well as reduced anxiety-like behavior in the elevated plus maze in rats. Preliminary intraperitonial administration of Semax (0.1 mg/kg) attenuates cognitive impairment caused by acute restrained stress, but it does not affect stress-induced changes in anxiety.
作者简介
N. Glazova
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
俄罗斯联邦, Moscow, 123182
E. Sebentsova
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
俄罗斯联邦, Moscow, 123182
D. Manchenko
Faculty of Biology
Email: nglevitskaya@gmail.com
俄罗斯联邦, Moscow, 119992
L. Andreeva
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
俄罗斯联邦, Moscow, 123182
L. Dergunova
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
俄罗斯联邦, Moscow, 123182
N. Levitskaya
Institute of Molecular Genetics; Faculty of Biology
编辑信件的主要联系方式.
Email: nglevitskaya@gmail.com
俄罗斯联邦, Moscow, 123182; Moscow, 119992
S. Limborska
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
俄罗斯联邦, Moscow, 123182
N. Myasoedov
Institute of Molecular Genetics
Email: nglevitskaya@gmail.com
俄罗斯联邦, Moscow, 123182