Permanent-Charge Generation Derivatization for the Analysis of Thiols by “Soft” Ionization Mass Spectrometry Methods
- 作者: Kozlov A.1, Borisov R.1, Zaikin V.1
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隶属关系:
- Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
- 期: 卷 74, 编号 14 (2019)
- 页面: 1396-1404
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183384
- DOI: https://doi.org/10.1134/S1061934819140065
- ID: 183384
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详细
A new method is proposed for the permanent-charge generation derivatization of thiols of different structures by a reaction with haloalkanes and dibromides. It was shown that 1,4-dibromobutane and 1,2-xylylene dibromide are the most effective alkylating agents, providing the formation of a stable five-membered ring with a positively charged sulfur atom. Such cations are readily detected by electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry. Sulfonium cations were further studied by tandem mass spectrometry using collision-induced dissociation (CID). Typical and specific CID directions for cyclic cations formed from thiols of different structures are revealed. They can be used to identify and quantify thiol analytes by the selected reaction monitoring method.
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作者简介
A. Kozlov
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: borisov@ips.ac.ru
俄罗斯联邦, Leninskii pr. 29, Moscow, 119991
R. Borisov
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: borisov@ips.ac.ru
俄罗斯联邦, Leninskii pr. 29, Moscow, 119991
V. Zaikin
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: borisov@ips.ac.ru
俄罗斯联邦, Leninskii pr. 29, Moscow, 119991