Optimization of N-acetylcysteine Determination by Ion Mobility Spectrometry using Central Composite Design
- 作者: Tehrani L.1, Sheibani A.1, Nazari A.2
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隶属关系:
- Department of Chemistry, Yazd Branch, Islamic Azad University
- Department of Art & Architectural, Yazd Branch, Islamic Azad University
- 期: 卷 73, 编号 10 (2018)
- 页面: 986-990
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182848
- DOI: https://doi.org/10.1134/S1061934818100118
- ID: 182848
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详细
In this study, a simple and rapid method for N-acetylcysteine (NAC) determination was proposed using positive corona discharge ion mobility spectrometry. To optimize cell and injection temperature, central composite design was used. Other parameters such as corona and drift voltage, carrier and drift gas flow rate, and pulse width were adjusted. The calibration curve was linear under optimum conditions in the range of 3–100 ng with a correlation coefficient (R2) of 0.99. The relative standard deviations were 8.1 and 6.1%, for 20 and 50 ng of analyte (n = 9), respectively. Limits of detection and quantification were 1 and 3 ng, respectively. The developed method was successfully applied for the determination of NAC in pharmaceutical and human plasma samples.
作者简介
L. Tehrani
Department of Chemistry, Yazd Branch, Islamic Azad University
Email: sheibani@iauyazd.ac.ir
伊朗伊斯兰共和国, Yazd
A. Sheibani
Department of Chemistry, Yazd Branch, Islamic Azad University
编辑信件的主要联系方式.
Email: sheibani@iauyazd.ac.ir
伊朗伊斯兰共和国, Yazd
A. Nazari
Department of Art & Architectural, Yazd Branch, Islamic Azad University
Email: sheibani@iauyazd.ac.ir
伊朗伊斯兰共和国, Yazd