Application of polyaniline–multiwalled carbon nanotubes composite fiber for determination of benzaldehyde in injectable pharmaceutical formulations by solid-phase microextraction GC–FID using experimental design
- 作者: Masoumi V.1, Mohammadi A.1,2, Khoshayand M.1,3, Ansari M.4
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隶属关系:
- Department of Drug and Food Control, Faculty of Pharmacy
- Nanotechnology Research Centre, Faculty of Pharmacy
- Pharmaceutical quality assurance research Centre, Faculty of Pharmacy
- Faculty of Pharmacy
- 期: 卷 72, 编号 3 (2017)
- 页面: 264-271
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182332
- DOI: https://doi.org/10.1134/S1061934817030133
- ID: 182332
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详细
A polyaniline–multiwalled carbon nanotubes composite fiber was electrodeposited onto a platinum wire using cyclic voltammetry. This fiber was used for headspace solid-phase microextraction combined with gas chromatography and flame ionization detector of trace levels of benzaldehyde in some injectable pharmaceutical formulations. Three solid-phase microextraction parameters including temperature, time and stirring rate were investigated simultaneously using a three-level-three-factor Box–Behnken as experimental design on the extraction capability. The as-made fiber has a lifetime of over 300 extractions without any obvious decline in extraction efficiency. At the optimum conditions (extraction temperature 60°C, extraction time 15 min, stirring rate 700 rpm), the method displays excellent linearity over the concentration range of 25–1000 ng/mL of benzaldehyde with RSD values ranging from 1.0 to 6.8%. The limits of quantitation and detection were 25 and 10 ng/mL, respectively.
作者简介
Vahideh Masoumi
Department of Drug and Food Control, Faculty of Pharmacy
Email: alimohammadi@tums.ac.ir
伊朗伊斯兰共和国, Tehran
Ali Mohammadi
Department of Drug and Food Control, Faculty of Pharmacy; Nanotechnology Research Centre, Faculty of Pharmacy
编辑信件的主要联系方式.
Email: alimohammadi@tums.ac.ir
伊朗伊斯兰共和国, Tehran; Tehran
Mohammad Khoshayand
Department of Drug and Food Control, Faculty of Pharmacy; Pharmaceutical quality assurance research Centre, Faculty of Pharmacy
Email: alimohammadi@tums.ac.ir
伊朗伊斯兰共和国, Tehran; Tehran
Mehdi Ansari
Faculty of Pharmacy
Email: alimohammadi@tums.ac.ir
伊朗伊斯兰共和国, Kerman