Determination of clonazepam in pharmaceutical preparations using simple high-throughput flow injection system
- 作者: Hadi H.1, Mouayed M.1
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隶属关系:
- Department of Chemistry, College of Science
- 期: 卷 72, 编号 2 (2017)
- 页面: 226-233
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182317
- DOI: https://doi.org/10.1134/S1061934817020058
- ID: 182317
如何引用文章
详细
This study was aimed at examining two flow injection-spectrophotometric systems (normal and reverse) for the determination of clonazepam (CLO) at the microgram level in pure and pharmaceutical dosage forms. The estimation of CLO has been developed by conjugating a normal (or reverse) flow injection analysis (nFIA or rFIA) and spectrophotometric detection with phloroglucinol as a coupling reagent. Beer’s law was obeyed over a range of 50–400 and 30–400 μg/mL. The limits of detection were 11 and 8 μg/mL and the sampling rates were 51 and 28 samples per hour for nFIA and rFIA respectively. Both systems were successfully applied for the determination of CLO in its commercially available dosage forms. A comparison between the proposed flow systems was also done. These simple and high throughput methods could be utilized for pharmaceutical analysis of CLO.
作者简介
Hind Hadi
Department of Chemistry, College of Science
编辑信件的主要联系方式.
Email: hindhadi13@yahoo.com
伊拉克, Jadriyah, Baghdad
Marwa Mouayed
Department of Chemistry, College of Science
Email: hindhadi13@yahoo.com
伊拉克, Jadriyah, Baghdad
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